A7250

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A7250

Sigma-Aldrich

 

N-Acetyl-L-cysteine

Sigma Grade, ≥99% (TLC), powder

Synonym:LNAC, NAC
CAS Number:616-91-1
Linear Formula:HSCH2CH(NHCOCH3)CO2H
Molecular Weight:163.19
Beilstein Registry Number:1724426
EC Number:210-498-3
MDL number:MFCD00004880
PubChem Substance ID:24277970

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Description

Biochem/physiol ActionsAntioxidant and mucolytic agent. Increases cellular pools of free radical scavengers. Reported to prevent apoptosis in neuronal cells but induce apoptosis in smooth muscle cells. Inhibits HIV replication. May serve as a substrate for microsomal glutathione transferase.

Properties

gradeSigma Grade
assay≥99% (TLC)
formpowder
mp106-108 °C(lit.)
solubilityH2O: 100 mg/mL with heating
storage temp.2-8°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Safety Statements22-24/25
WGK Germany2
RTECSHA1660000

References

referenceFerrari, G., et al., N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. J. Neurosci. 15, 2857-2866, (1995)
 Tsai, J.C., et al., Induction of apoptosis by pyrrolidinedithiocarbamate and N-acetylcysteine in vascular smooth muscle cells. J. Biol. Chem. 271, 3667-3670, (1996)
 Roederer, M., et al., Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proc. Natl. Acad. Sci. U. S. A. 87, 4884-4888, (1990)
 Weinander, R., et al., Identification of N-acetylcysteine as a new substrate for rat liver microsomal glutathione transferase. A study of thiol ligands. J. Biol. Chem. 269, 71-76, (1994)
MerckMerck 13,90
BeilsteinBeil. 4,IV,3160
 FT-IR 2 (1), 1332:A / FT-IR 1 (1), 786:D / FT-NMR 1 (1), 1282:B / IR-Spectra (3), 466:D / IR-Spectra (2), 413:E / NMR-Reference 2 (1), 659:D / RegBook 1 (1), 919:G / Sax 6, 107 / Sigma FT-IR 1 (1), 4:A / Structure Index 1, 142:C:7